BASIGIN is a receptor essential for erythrocyte invasion by Plasmodium falciparum
By Cécile Crosnier, Leyla Y. Bustamante, S. Bartholdson, Amy K. Bei, Michel Theron, M. Uchikawa, S. Mboup, O. Ndir, Dominic P. Kwiatkowski, M. Duraisingh and 2 more. Nature, 2011
659 citations recorded by the source corpus.
Erythrocyte invasion by Plasmodium falciparum is central to the pathogenesis of malaria. Invasion requires a series of extracellular recognition events between erythrocyte receptors and ligands on the merozoite, the invasive form of the parasite. None of the few known receptor–ligand interactions involved are required in all parasite strains, indicating that the parasite is able to access multiple redundant invasion pathways. Here, we show that we have identified a receptor–ligand pair that is essential for erythrocyte invasion in all tested P. falciparum strains. By systematically screening a library of erythrocyte proteins, we have found that the Ok blood group antigen, basigin, is a receptor for PfRh5, a parasite ligand that is essential for blood stage growth. Erythrocyte invasion was potently inhibited by soluble basigin or by basigin knockdown, and invasion could be completely blocked using low concentrations of anti-basigin antibodies; importantly, these effects were observed across all laboratory-adapted and field strains tested. Furthermore, Oka− erythrocytes, which express a basigin variant that has a weaker binding affinity for PfRh5, had reduced invasion efficiencies. Our discovery of a cross-strain dependency on a single extracellular receptor–ligand pair for erythrocyte invasion by P. falciparum provides a focus for new anti-malarial therapies.
Subfields: Immunology, Molecular Biology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/d523cf968c864e0523793ebac928a0d8a1253cd0
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In Molecular Biology
Citations in the corpus
- A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions (2020, background): “Multiple groups have shown that ELISA-based binding assays have a remarkably low false-positive rate (Wojtowicz et al., 2007; Bushell et al., 2008; Söllner andWright, 2009;Martin et al., 2010; Crosnier et al., 2011; Özkan et al., 2013; Visser et al., 2015; Ranaivoson et al., 2019).”
- The SLC16 gene family - structure, role and regulation in health and disease. (2013, background): “Basigin has been implicated in signalling pathways in inflammation, and as a receptor for viruses, including for HIV, and for erythrocyte invasion by Plasmodium falciparum (Crosnier et al., 2011).”
- Malaria: Biology and Disease. (2016, positive): “PfRh5 binds to the host receptor basigin and it plays an essential role in merozoite invasion (Crosnier et al., 2011).”