A framework for advancing our understanding of cancer-associated fibroblasts
By Erik Sahai, I. Astsaturov, E. Cukierman, D. DeNardo, M. Egeblad, Ronald M. Evans, D. T. Fearon, F. Greten, S. Hingorani, T. Hunter and 19 more. Nature Reviews. Cancer, 2020
3,153 citations recorded by the source corpus.
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment. This Consensus Statement highlights the importance of cancer-associated fibroblasts in cancer biology and progression, and issues a call to action for all cancer researchers to standardize assays and report metadata in studies of cancer-associated fibroblasts to advance our understanding of this important cell type in the tumour microenvironment.
Subfields: Immunology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/d4d5a5e5af529b6782e5c9b6874561fa871c7025
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Citations in the corpus
- Dynamic EMT: a multi‐tool for tumor progression (2021, neutral): “CAFs can be categorized into different subpopulations with specific functions and spatial organization (Lambrechts et al , 2018; Elyada et al , 2019; Sahai et al , 2020).”
- Nanomedicine in cancer therapy (2023, background): “353,354 In a recent study, Li et al. developed a multimodal phototheranostic nanoagent by coating semiconducting polymeric nanoparticles (SPNs) with cell membranes derived from activated fi broblasts.”
- Overcoming Endocrine Resistance in Breast Cancer (2020, neutral): “, 2014), and 3) microenvironmental components that affect drug sensitivity (Hirata et al., 2015; Kalluri, 2016; Ruffell and Coussens, 2015; Sahai et al., 2020).”
- Physical traits of cancer (2020, background): “In fibrotic tumors, CAFs are primarily responsible for collagen production, and these cells have more actin stress fibers, alpha smoothmuscle actin, and focal adhesions than nonactivated fibroblasts (14, 98).”
- Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer. (2020, background): “Cancer-Associated Fibroblasts (CAF) represent one of the most abundant components in adenocarcinomas and play key pro-tumorigenic functions (1-6).”
- Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer (2021, background): “originated mostly from the primitive mesenchyme of the mesoderm,(14) and, in some cases, partially from the neural crest of the ectoderm.(15,16) Indeed, the definition of fibroblasts is constantly changing.”
- Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “Recently, the technology of multiplexed mRNA probes has been rapidly developed, and thus accurate quantitative methods for the detection of CAFs, in the long term, are promising [87].”