Trends in Human Fecal Carriage of Extended-Spectrum β-Lactamases in the Community: Toward the Globalization of CTX-M

By P. Woerther, C. Burdet, E. Chachaty, A. Andremont. Clinical Microbiology Reviews, 2013

669 citations recorded by the source corpus.

SUMMARY In the last 10 years, extended-spectrum β-lactamase-producing enterobacteria (ESBL-E) have become one of the main challenges for antibiotic treatment of enterobacterial infections, largely because of the current CTX-M enzyme pandemic. However, most studies have focused on hospitalized patients, though today it appears that the community is strongly affected as well. We therefore decided to devote our investigation to trends in ESBL-E fecal carriage rates and comprehensively reviewed data from studies conducted on healthy populations in various parts of the world. We show that (i) community ESBL-E fecal carriage, which was unknown before the turn of the millennium, has since increased significantly everywhere, with developing countries being the most affected; (ii) intercontinental travel may have emphasized and globalized the issue; and (iii) CTX-M enzymes, especially CTX-M-15, are the dominant type of ESBL. Altogether, these results suggest that CTX-M carriage is evolving toward a global pandemic but is still insufficiently described. Only a better knowledge of its dynamics and biology will lead to further development of appropriate control measures.

Subfields: Applied Microbiology and Biotechnology, Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d4d05f6a459fce1c07b111bd35d512f6b77a0d51

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In Applied Microbiology and Biotechnology

1. P. Bradford
2. K. Bush
3. W. Reygaert

In Molecular Medicine

1. P. Bradford
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Citations in the corpus

• Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer (2016, background): “These genes are now ubiquitous in humans (Woerther et al., 2013), animals, and the environment (Hartmann et al., 2012).”
• Epidemiology of β-Lactamase-Producing Pathogens (2020, background): “In contrast, KPC serine carbapenemases are present more frequently in the Americas, the Mediterranean countries, and China, whereas NDM metallo- -lactamases are more prevalent in the Indian subcontinent and Eastern Europe.”