Arsenic Trioxide Controls the Fate of the PML-RARα Oncoprotein by Directly Binding PML
By Xiao-Wei Zhang, Xiao-jing Yan, Zi-ren Zhou, Fei-Fei Yang, Ziyu Wu, Hong Sun, Wenxue Liang, A. Song, V. Lallemand-Breitenbach, M. Jeanne and 11 more. Science, 2010
721 citations recorded by the source corpus.
Subfields: Cell Biology, Hematology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d47146f863563f4ae41bc181cbcedc4dfb22b010
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In Molecular Biology
Citations in the corpus
- TRIM proteins and cancer (2011, background): “Recently, it has been reported that arsenic trioxide (As 2 O 3 ) binds to cysteines in the Zn-finger domain of PML or PML–RARα, resulting in the induction of PML oligomerization and the promotion of sumoylation, which probably leads to enhanced ubiquitylation and degradation of PML and PML–RAR”