Protein engineering to improve the thermostability of glucoamylase from Aspergillus awamori based on molecular dynamics simulations.

By Hsuan-Liang Liu, Wen-Chi Wang. 2003

66 citations recorded by the source corpus.

Subfields: Biotechnology, Materials Chemistry, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Materials Chemistry

1. Chun-chao Lo
2. Xiuwen Liu
3. Wei Wu
4. Jinfeng Zhang
5. Yang Chen
6. Chenran Wang
7. Yuan Zhang

In Molecular Biology

1. Daniel R. Weinberger
2. Chun-chao Lo
3. Xiuwen Liu
4. Wei Wu
5. Jinfeng Zhang
6. Yang Chen
7. Chenran Wang
8. Yuan Zhang

Citations in the corpus

• ProDCoNN: Protein design using a convolutional neural network (2019, background): “Although it has been suggested that native sequences are likely optimal for a given structure, 65 the fact that many proteins can be engineered to more stable mutants 66-68 indicates that in terms of stability, many protein sequences are not optimal.”
• Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. (2004, background): “Protein engineering studies have shown that an enzyme is more stable if it has a more hydrophobic amino acid residue on its surface (Liu and Wang 2003; Machius et al. 2003).”