Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery
By R. Donnelly, T. R. Singh, M. Garland, K. Migalska, R. Majithiya, C. McCrudden, P. Kole, T. Mahmood, H. McCarthy, A. Woolfson. Advanced Functional Materials, 2012
629 citations recorded by the source corpus.
Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch‐type drug reservoirs to the dermal microcirculation. Importantly, such microneedles, which can be fabricated in a wide range of patch sizes and microneedle geometries, can be easily sterilized, resist hole closure while in place, and are removed completely intact from the skin. Delivery of macromolecules is no longer limited to what can be loaded into the microneedles themselves and transdermal drug delivery is now controlled by the crosslink density of the hydrogel system rather than the stratum corneum, while electrically modulated delivery is also a unique feature. This technology has the potential to overcome the limitations of conventional microneedle designs and greatly increase the range of the type of drug that is deliverable transdermally, with ensuing benefits for industry, healthcare providers and, ultimately, patients.
Subfields: Dermatology, Pharmaceutical Science
View Paper: https://www.semanticscholar.org/paper/d43c31c07b2a891befa0747cef650d0fdad7ddd7
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In Dermatology
In Pharmaceutical Science
- R. Donnelly
- Maelíosa T. C. McCrudden
- Ahlam Zaid Alkilani
- E. Larrañeta
- A. Courtenay
- Mark R. Prausnitz
- K. van der Maaden
- W. Jiskoot
Citations in the corpus
- Microneedles: A New Frontier in Nanomedicine Delivery (2016, positive): “Hydrogel-forming MN arrays have been employed to deliver a wide range of different molecules from small molecules (91,101,102,105) to high molecular weight compounds (101,102,105).”
- Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum (2015, background): “A wide variety of MN types and designs have been shown to be effective for the transdermal delivery of a diverse range of molecules, both in vitro and in vivo [10,12].”
- Engineering Microneedle Patches for Vaccination and Drug Delivery to Skin. (2017, methodology): “In the poke and release approach, drugs are encapsulated in the patch backing and, in some cases, the microneedles to enable slow drug release while the patch is adhered to the skin (54).”