Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology
By P. Davies. Nature Clinical Practice Cardiovascular Medicine, 2008
1,205 citations recorded by the source corpus.
Endothelium lining the cardiovascular system is highly sensitive to hemodynamic shear stresses that act at the vessel luminal surface in the direction of blood flow. Physiological variations of shear stress regulate acute changes in vascular diameter and when sustained induce slow, adaptive, structural-wall remodeling. Both processes are endothelium-dependent and are systemically and regionally compromised by hyperlipidemia, hypertension, diabetes and inflammatory disorders. Shear stress spans a range of spatiotemporal scales and contributes to regional and focal heterogeneity of endothelial gene expression, which is important in vascular pathology. Regions of flow disturbances near arterial branches, bifurcations and curvatures result in complex spatiotemporal shear stresses and their characteristics can predict atherosclerosis susceptibility. Changes in local artery geometry during atherogenesis further modify shear stress characteristics at the endothelium. Intravascular devices can also influence flow-mediated endothelial responses. Endothelial flow-induced responses include a cell-signaling repertoire, collectively known as mechanotransduction, that ranges from instantaneous ion fluxes and biochemical pathways to gene and protein expression. A spatially decentralized mechanism of endothelial mechanotransduction is dominant, in which deformation at the cell surface induced by shear stress is transmitted as cytoskeletal tension changes to sites that are mechanically coupled to the cytoskeleton. A single shear stress mechanotransducer is unlikely to exist; rather, mechanotransduction occurs at multiple subcellular locations.
Subfields: Cardiology and Cardiovascular Medicine, Immunology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/d434b47efabad22d5b20737b8e89104ce9d6a86a
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Citations in the corpus
- Actin dynamics, architecture, and mechanics in cell motility. (2014, background): “The narrowing of arteries during atherosclerosis happens at the site of arterial branches and curvature where cells are put under tension by blood flow (74, 149).”
- The Pathology of Neoatherosclerosis in Human Coronary Implants: Bare Metal and Drug-Eluting Stents (2011, neutral): “0 Overlapping stents 36 (18) 63 (30) Underlying plaque morphology Ruptured plaque/TCFA 26 (13) 49 (23) Fibroatheroma 86 (44) 104 (50)”
- Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. (2011, background): “These structures could include the glycocalyx, the primary cilia, and mechanosensitive ion channels (19).”
- Wound Healing: A Cellular Perspective. (2019, background): “The core of the thrombus usually contains highly activated P-selectin expressing platelets, and the borders of the thrombus contain fewer activated P-selectin negative platelets (80).”