The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.

By A. Malfait, R. Gallily, P. F. Sumariwalla, A. S. Malik, E. Andreakos, R. Mechoulam, M. Feldmann. Proceedings of the National Academy of Sciences of the United States of America, 2000

636 citations recorded by the source corpus.

Subfields: Pharmacology

View Paper: https://www.semanticscholar.org/paper/d404104f57eb54f7155a2d0972ecfd6fc1639f7b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pharmacology

1. V. Di Marzo
2. T. Klein
3. George Kunos
4. P. Pacher
5. S. Batkai
6. K. Mackie
7. R. Mechoulam
8. R. Pertwee

Citations in the corpus

• Cannabinoid-based drugs as anti-inflammatory therapeutics (2005, background): “sativa that has anti-inflammatory potential is cannabidio”
• Pharmacokinetics and Pharmacodynamics of Cannabinoids (2003, background): “1 Phytocannabinoids Cannabidiol (CBD) is a nonpsychotropic cannabinoid, for which sedating,[236] antiepileptic,[237] antidystonic,[238] antiemetic[239] and anti-inflammatory[240] effects have been observed.”
• Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration (2003, background): “, 2001), whereas the immunomodulatory effects are attributable to THC and CBN acting at CB2 receptors expressed by immune cells and to CBD acting on abn-CBD receptors (Kaminski, 1998; Klein et al., 1998; Buckley et al., 2000; Malfait et al., 2000).”
• The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, background): “Treatment with cannabidiol or its more potent dimethylheptyl derivative (HU-320) reduced an LPS-induced increase in serum TNF-α and immune function and effectively blocked the progression of collagen-induced arthritis in mice (Malfait et al., 2000; Sumariwalla et al., 2004).”
• Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide (2001, background): “CBD also induces anti-in¯ammatory e ects, a possible explanation for this property being its capability of modulating the release of anti-in¯ammatory or pro-in¯ammatory mediators (Srivas- tava et al., 1998, Malfait et al., 2000).”