Malaria transmission‐blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst production

By S. Ekşi, B. Czesny, G. van Gemert, R. Sauerwein, W. Eling, K. Williamson. 2006

175 citations recorded by the source corpus.

Subfields: Immunology, Public Health, Environmental and Occupational Health

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In Immunology

1. P. Duffy
2. Stefan H. I. Kappe

In Public Health, Environmental and Occupational Health

1. P. Duffy
2. Stefan H. I. Kappe
3. Silvia A. Arredondo

Citations in the corpus

• Structural and Immunological Characterization of Recombinant 6-Cysteine Domains of the Plasmodium falciparum Sexual Stage Protein Pfs230* (2016, background): “Surface and Modified Surface Immunofluorescence Assay— Surface immunofluorescence assay analysis was performed essentially as reported (22).”
• Transmission-Blocking Vaccines: Harnessing Herd Immunity for Malaria Elimination (2021, unknown): “berghei impairs male gamete fertility [34,35].”
• Three Members of the 6-cys Protein Family of Plasmodium Play a Role in Gamete Fertility (2010, background): “falciparum mutants lacking P230 expression produce male gametes that fail to attach to erythrocytes resulting in a reduced formation of the characteristic ‘exflagellation centres’ and reduced oocyst formation in mosquitoes [27].”
• The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle (2016, background): “falciparum, exflagellating males are unable to bind to erythrocytes to establish exflagellation centers, which are important for fertilization (Eksi et al., 2006) and, in Plasmodium berghei, ΔP230 male gametes do not recognize female gametes, whereas ΔP230 female gametes have no apparent phenotype (”
• Plasmodium 6-Cysteine Proteins: Functional Diversity, Transmission-Blocking Antibodies and Structural Scaffolds (2022, background): “It remains unclear, however, whether this effect is due to the loss of Pfs48/45 itself or due to an absence of Pfs230 from the parasite surface, which is anchored to the membrane by its interaction with Pfs48/45 (Eksi et al., 2006).”
• Identification of domains within Pfs230 that elicit transmission blocking antibody responses (2019, background): “In addition, the disruption of Pfs230 gene resulted in >90% reduction in oocyst numbers per mosquito compared to that in wild type parasites [5].”
• Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax (2011, background): “Pfs230 has been suggested to be associated with male gamete’s binding to human erythrocyte during the formation of exflagellation center [20].”
• Structure of the Plasmodium 6-cysteine s48/45 domain (2012, background): “Deletion of either Pfs48/45 or Pfs230 greatly reduces zygote formation (16, 17).”