Structural features of activated GPCR signaling complexes.

By Jingjing Wang, T. Hua, Zhi-jie Liu. 2020

61 citations recorded by the source corpus.

G protein-coupled receptors (GPCRs) couple to diverse heterotrimeric G protein subtypes and then activate downstream signaling pathways in classical GPCR activation. It has also been found that GPCRs transduce signals through different regulatory proteins, such as arrestins. Recently, owing to the breakthroughs in cryo-electron macroscopy (Cryo-EM), numerous structures of GPCR-G protein or GPCR-arrestin complexes have been deciphered. In this review, we summarize most of reported GPCR signaling complex structures, with an emphasis on the structural features of rhodopsin-like GPCR activation and G protein-binding/arrestin-binding modes, to illustrate the activation and signaling mechanism of rhodopsin-like GPCRs.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Spectroscopy

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Jens Meiler
2. Hassane S. Mchaourab

In Molecular Biology

1. Diego del Alamo
2. Jens Meiler
3. Davide Sala
4. Hassane S. Mchaourab
5. Björn Wallner
6. David Baker

In Spectroscopy

1. Jens Meiler
2. Davide Sala
3. Diego del Alamo
4. Hassane S. Mchaourab

Citations in the corpus

• Sampling alternative conformational states of transporters and receptors with AlphaFold2 (2022, background): “For G- protein-coupled receptors (GPCRs), ligand binding on the extra-cellular side triggers structural rearrangements on the intracellular side that initiate downstream signaling ( Wang et al., 2020 ; Gusach et al., 2020 ).”