Molecular genetics and diagnosis of thyroid cancer

By Y. Nikiforov, M. Nikiforova. Nature Reviews Endocrinology, 2011

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2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer (2009, positive): “Although BRAF single mutation testing has been estimated to have a specificity of approximately 99% (pooled data from 1117 nodules with histopathologic confirmation from multiple studies), the sensitivity has been deemed to be too low to reliably rule out the presence of malignancy (169).”
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer (2015, background): “The clinical behavior of FTC in children is distinct from PTC. Pediatric FTC may be less aggressive than PTC and is generally associated with less advanced disease, fewer distant metastases, and a lower rate of recurrence (9, 11, 50, 167, 376).”