The chemical basis of ferroptosis

By M. Conrad, D. Pratt. Nature Chemical Biology, 2019

870 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/d37ea8440cc35306269b274f2d90aa72781320cc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. W. Zou

In Molecular Biology

1. W. Zou
2. Wen Wang

In Pulmonary and Respiratory Medicine

1. Brent R. Stockwell

Citations in the corpus

• Ferroptosis in cancer therapy: a novel approach to reversing drug resistance (2022, background): “The products of lipid peroxidation cause membrane instability and permeabilization and eventually lead to cell death [26].”
• Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, neutral): “82,83 Iron metabolism and toxicity .”
• CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 (2022, background): “Lysophosphatidylcholine acyltransferase 3 (LPCAT3) and lipoxygenases (LOX) are involved in the incorporation of arachidonyl-CoAs into phospholipids on membranes and oxidation of these phospholipids, respectively (Conrad and Pratt, 2019; Ingold et al., 2018; Wenzel et al., 2017).”
• The cell biology of ferroptosis (2024, neutral): “Free intracellular iron or iron-containing enzymes react with oxygen and polyunsaturated fatty acid (PUFA)- containing lipids to generate high levels of membrane lipid peroxides — the defining feature of ferroptosis in relation to other forms of cell death 3 (Box 1).”