In vivo recordings of brain activity using organic transistors
By D. Khodagholy, Thomas Doublet, Pascale P. Quilichini, M. Gurfinkel, P. Leleux, A. Ghestem, Esma Ismailova, T. Hervé, S. Sanaur, Christophe Bernard and 1 more. Nature Communications, 2013
908 citations recorded by the source corpus.
In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic purposes and for brain-machine interfaces. Organic electronic devices constitute a promising candidate because of their mechanical flexibility and biocompatibility. Here we demonstrate the engineering of an organic electrochemical transistor embedded in an ultrathin organic film designed to record electrophysiological signals on the surface of the brain. The device, tested in vivo on epileptiform discharges, displayed superior signal-to-noise ratio due to local amplification compared with surface electrodes. The organic transistor was able to record on the surface low-amplitude brain activities, which were poorly resolved with surface electrodes. This study introduces a new class of biocompatible, highly flexible devices for recording brain activity with superior signal-to-noise ratio that hold great promise for medical applications. Flexible organic electronic devices have the potential to serve as biosensors in living animals. Khodagholy et al. show that organic transistors can be used to record brain activity in rats and demonstrate that they have a superior signal-to-noise ratio compared with electrodes due to local signal amplification.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/d3516eec4702f61fd72d5acbe3016d6159479d7c
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In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
Citations in the corpus
- Progress in Brain Computer Interface: Challenges and Opportunities (2019, background): “A novel organic electrochemical transistor-based sensor enables to collect neural signals directly from the brain surface [130].”
- Structural control of mixed ionic and electronic transport in conducting polymers (2016, neutral): “Owing to their high transconductance 1 , these devices have been shown to be efficient transducers of biological activity, with applications ranging from neural interfacing 2,3 to biosensing 4 .”