Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds
By P. Grandjean, E. Andersen, E. Budtz-Jørgensen, F. Nielsen, K. Mølbak, P. Weihe, C. Heilmann. Journal of the American Medical Association (JAMA), 2012
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Context Perfluorinated compounds (PFCs) have emerged as important food contaminants. They cause immune suppression in a rodent model at serum concentrations similar to those occurring in the US population, but adverse health effects of PFC exposure are poorly understood. Objective To determine whether PFC exposure is associated with antibody response to childhood vaccinations. Design, Setting, and Participants Prospective study of a birth cohort from the National Hospital in the Faroe Islands. A total of 656 consecutive singleton births were recruited during 1997-2000, and 587 participated in follow-up through 2008. Main Outcome Measures Serum antibody concentrations against tetanus and diphtheria toxoids at ages 5 and 7 years. Results Similar to results of prior studies in the United States, the PFCs with the highest serum concentrations were perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Among PFCs in maternal pregnancy serum, PFOS showed the strongest negative correlations with antibody concentrations at age 5 years, for which a 2-fold greater concentration of exposure was associated with a difference of −39% (95% CI, −55% to −17%) in the diphtheria antibody concentration. PFCs in the child’s serum at age 5 years showed uniformly negative associations with antibody levels, especially at age 7 years, except that the tetanus antibody level following PFOS exposure was not statistically significant. In a structural equation model, a 2-fold greater concentration of major PFCs in child serum was associated with a difference of −49% (95% CI, −67% to −23%) in the overall antibody concentration. A 2-fold increase in PFOS and PFOA concentrations at age 5 years was associated with odds ratios between 2.38 (95% CI, 0.89 to 6.35) and 4.20 (95% CI, 1.54 to 11.44) for falling below a clinically protective level of 0.1 IU/mL for tetanus and diphtheria antibodies at age 7 years. Conclusion Elevated exposures to PFCs were associated with reduced humoral immune response to routine childhood immunizations in children aged 5 and 7 years.
Subfields: Environmental Chemistry, Pharmaceutical Science, Water Science and Technology
View Paper: https://www.semanticscholar.org/paper/d351191c939deb1656186667124fec5560df4531
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In Water Science and Technology
Citations in the corpus
- Per- and polyfluoroalkyl substances in water and wastewater: A critical review of their global occurrence and distribution (2021, background): “…in the blood serum of residents living near an FPP. PFAS exposure may result in decreased spleen and thymus weights and cellularity, reduced production of specific antibodies, reduced survival after influenza infection, immunosuppression, and altered cytokine production (Grandjean et al., 2012).”
- Emerging contaminants: A One Health perspective (2024, neutral): “477,481,482 A most recent study showed that prenatal exposure to PFOS and PFOA increased the risk of non-atopic asthma at the age of 6 years by up to 2-fold.”
- Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research (2020, background): “The authors noted that a “2‐fold greater concentration of major PFCs [perfluorinated compounds] in child serum was associated with a difference of −49% (95% CI, −67% to −23%) in the overall antibody concentration” (Grandjean et al. 2012).”