Use of Metal Oxide Nanoparticle Band Gap to Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation
By Haiyuan Zhang, Zhaoxia Ji, Tian Xia, Huan Meng, C. Low-Kam, Rong Liu, Suman Pokhrel, Sijie Lin, Xiang Wang, Yu-Pei Liao and 9 more. ACS Nano, 2012
774 citations recorded by the source corpus.
We demonstrate for 24 metal oxide (MOx) nanoparticles that it is possible to use conduction band energy levels to delineate their toxicological potential at cellular and whole animal levels. Among the materials, the overlap of conduction band energy (Ec) levels with the cellular redox potential (−4.12 to −4.84 eV) was strongly correlated to the ability of Co3O4, Cr2O3, Ni2O3, Mn2O3 and CoO nanoparticles to induce oxygen radicals, oxidative stress and inflammation. This outcome is premised on permissible electron transfers from the biological redox couples that maintain the cellular redox equilibrium to the conduction band of the semiconductor particles. Both single parameter cytotoxic as well as multi-parameter oxidative stress assays in cells showed excellent correlation to the generation of acute neutrophilic inflammation and cytokine responses in the lungs of CB57 Bl/6 mice. Co3O4, Ni2O3, Mn2O3 and CoO nanoparticles could also oxidize cytochrome c as a representative redox couple involved in redox homeostasis. While CuO and ZnO generated oxidative stress and acute pulmonary inflammation that is not predicted by Ec levels, the adverse biological effects of these materials could be explained by their solubility, as demonstrated by ICP-MS analysis. Taken together, these results demonstrate, for the first time, that it is possible to predict the toxicity of a large series of MOx nanoparticles in the lung premised on semiconductor properties and an integrated in vitro/in vivo hazard ranking model premised on oxidative stress. This establishes a robust platform for modeling of MOx structure-activity relationships based on band gap energy levels and particle dissolution. This predictive toxicological paradigm is also of considerable importance for regulatory decision-making about this important class of engineered nanomaterials.
Subfields: Electrochemistry, Materials Chemistry, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/d34525afd68070fcae4103931929f4a9ff8646f4
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In Electrochemistry
In Materials Chemistry
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Citations in the corpus
- Mechanisms of Silver Nanoparticle Release, Transformation and Toxicity: A Critical Review of Current Knowledge and Recommendations for Future Studies and Applications (2013, background): “Indeed a recent paper suggests that a nanomaterials‘ conduction band energy levels (band gap) and particle dissolution could be the basis of predicting its oxidative stress potential and subsequent pulmonary inflammation potential as the basis of a predictive toxicity platform [136].”
- Comparative environmental fate and toxicity of copper nanomaterials (2017, methodology): “8% in Dulbecco's modified Eagle medium within the experimental time frame (24 h) (Zhang et al., 2012).”