Codeine intoxication associated with ultrarapid CYP2D6 metabolism.

By Y. Gasche, Y. Daali, M. Fathi, A. Chiappe, S. Cottini, P. Dayer, J. Desmeules. New England Journal of Medicine, 2004

681 citations recorded by the source corpus.

Subfields: Organic Chemistry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d3246cb423b92873bc697c2a887027540b5406e8

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In Pharmacology

1. M. Schwab
2. Ulrich M. Zanger

Citations in the corpus

• Pharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision Medicine (2016, background): “more devastating in UMs who are lactating mothers because the normal codeine dose can translate into fatal morphine concentrations into the breast milk [56].”
• Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. (2013, result): “Conversely, increased effectiveness of codeine with sometimes life-threatening opioid intoxication was observed in patients with multiple CYP2D6 gene copies but also in neonates whose breastfeeding mothers were genetic CYP2D6 UMs, consistent with higher rates of conversion to morphine in patients wi”