Dose-Response Between Physical Activity and Risk of Coronary Heart Disease: A Meta-Analysis
By J. Sattelmair, Jeremy Pertman, E. Ding, H. Kohl, William L. Haskell, I. Lee. Circulation, 2011
992 citations recorded by the source corpus.
Background No reviews have quantified the specific amounts of physical activity required for lower risks of coronary heart disease when assessing the dose-response relation. Instead, previous reviews have used qualitative estimates such as low, moderate, and high physical activity. Methods and Results We performed an aggregate data meta-analysis of epidemiological studies investigating physical activity and primary prevention of CHD. We included prospective cohort studies published in English since 1995. After reviewing 3194 abstracts, we included 33 studies. We used random-effects generalized least squares spline models for trend estimation to derive pooled dose-response estimates. Among the 33 studies, 9 allowed quantitative estimates of leisure-time physical activity. Individuals who engaged in the equivalent of 150 min/wk of moderate-intensity leisure-time physical activity (minimum amount, 2008 US federal guidelines) had a 14% lower coronary heart disease risk (relative risk, 0.86; 95% confidence interval, 0.77 to 0.96) compared with those reporting no leisure-time physical activity. Those engaging in the equivalent of 300 min/wk of moderate-intensity leisure-time physical activity (2008 US federal guidelines for additional benefits) had a 20% (relative risk, 0.80; 95% confidence interval, 0.74 to 0.88) lower risk. At higher levels of physical activity, relative risks were modestly lower. People who were physically active at levels lower than the minimum recommended amount also had significantly lower risk of coronary heart disease. There was a significant interaction by sex (P=0.03); the association was stronger among women than men. Conclusions These findings provide quantitative data supporting US physical activity guidelines that stipulate that “some physical activity is better than none” and “additional benefits occur with more physical activity.”
Subfields: Cardiology and Cardiovascular Medicine, Complementary and alternative medicine, Physiology
View Paper: https://www.semanticscholar.org/paper/d3241e0480f6b558559441d8fe887d2bebd193fe
How researchers see this paper
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In Cardiology and Cardiovascular Medicine
In Complementary and alternative medicine
In Physiology
- Renee H. Rhodes
- S. Bredin
- Adrian Bauman
- Elizabeth J Lyons
- Johannes Siegrist
- Massimo F. Piepoli
- Jian Li
- Ian Janssen
Citations in the corpus
- 2016 European Guidelines on cardiovascular disease prevention in clinical practice (2017, positive): “1 Aerobic physical activity Aerobic PA, the most studied and recommended modality, with a beneficial dose– response effect on prognosis [259, 260, 268], consists of movements of large muscle mass in a rhythmic manner for a sustained period.”
- Behavior Change Techniques Implemented in Electronic Lifestyle Activity Monitors: A Systematic Content Analysis (2014, positive): “Even small increases in activity at a population level could have far-reaching positive impacts on chronic diseases such as diabetes, cardiovascular diseases, and several cancers [1-4].”
- Physical Activity and Risk of Cardiovascular Disease—A Meta-Analysis of Prospective Cohort Studies (2012, background): “In addition, few explored the dose-response relationship [39,40].”