Contribution of Organofluorine Compounds to Pharmaceuticals
By M. Inoue, Yuji Sumii, N. Shibata. ACS Omega, 2020
1,216 citations recorded by the source corpus.
Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in the 1980s, fluorine-containing pharmaceuticals, which are also known as fluoro-pharmaceuticals, have been attracting attention for more than half of a century. Presently, about 20% of the commercial pharmaceuticals are fluoro-pharmaceuticals. In this mini-review, we analyze the prevalence of fluoro-pharmaceuticals in the market and categorize them into several groups based on the chemotype of the fluoro-functional groups, their therapeutic purpose, and the presence of heterocycles and/or chirality to highlight the structural motifs, patterns, and promising trends in fluorine-based drug design. Our database contains 340 fluoro-pharmaceuticals, from the first fluoro-pharmaceutical, Florinef, to the latest fluoro-pharmaceuticals registered in 2019 and drugs that have been withdrawn. The names and chemical structures of all the 340 fluorinated drugs discussed are provided in the Supporting Information.
Subfields: Organic Chemistry, Pharmaceutical Science
View Paper: https://www.semanticscholar.org/paper/d2f777e9375d53d2baa4cf6c521e65f1d6a29168
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In Organic Chemistry
In Pharmaceutical Science
Citations in the corpus
- Per- and polyfluoroalkyl substances in the environment (2022, neutral): “2) (11, 12).”
- Current Contributions of Organofluorine Compounds to the Agrochemical Industry (2020, background): “This analysis is somewhat different to the database of fluoro-pharmaceuticals (Inoue et al., 2020), where the contribution of fluoro-functionalized aliphatic compounds with F and CF3 groups are as abundant as the fluoro-functionalized aromatics.”