Dose translation from animal to human studies revisited
By Shannon R. Reagan-Shaw, M. Nihal, N. Ahmad. The FASEB Journal, 2007
5,969 citations recorded by the source corpus.
Subfields: Geriatrics and Gerontology, Oncology, Physiology
View Paper: https://www.semanticscholar.org/paper/d26c665258fe6cd39373fdee85f269f0912cd62d
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Citations in the corpus
- A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice (2014, background): “Singletons (OTUs with a unique sequence occurring only once among all reads) were discarded at this step.”
- Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile (2012, methodology): “Rats received single intravenous doses of NPs at 1000, 1500, or 2000 mg/kg [about 6000, 9000, and 12,000 mg/m(2), respectively, corresponding to up to 20 g of NP in an adult human of average body surface area (32)] and were monitored for clinical observations, changes in body weight, and blood chemi”
- Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis (2014, neutral): “In our study, metformin was administered to drinking water at a concentration of 1.25 mg/ml, approximately 250 mg/kg. Conversion of doses from mice to human is achieved using a formula based on body surface area normalization (Reagan-Shaw et al., 2008).”