Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution
By B. Koel, D. Burke, T. Bestebroer, S. van der Vliet, G. Zondag, Gaby Vervaet, E. Skepner, N. Lewis, M. Spronken, C. Russell and 8 more. Science, 2013
608 citations recorded by the source corpus.
Subfields: Epidemiology, Immunology
View Paper: https://www.semanticscholar.org/paper/d257f5a374ea8a83c39055ebe317dfcbcdb875b1
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In Epidemiology
- F. Krammer
- Jesse D. Bloom
- James O. Lloyd-Smith
- Richard A. Neher
- Boris I. Shraiman
- C. Russell
- Trevor Bedford
- P. Palese
In Immunology
Citations in the corpus
- Development of Influenza B Universal Vaccine Candidates Using the “Mosaic” Hemagglutinin Approach (2019, background): “These major antigenic sites play an immunodominant role in eliciting antibody responses in the host (37, 38).”
- Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin (2019, background): “Prior work has also noted that these two sites are important for antigenic recognition by ferret sera (Koel et al., 2013).”
- Modeling infectious disease dynamics in the complex landscape of global health (2015, background): “Molecular epidemiological studies often treat pathogen genetic variation as simply reflecting the underlying transmission process, whereas in reality such variation may play an important role in determining transmission dynamics, as exemplified by escape from herd immunity by influenza A virus (31).”
- Predicting evolution from the shape of genealogical trees (2014, background): “It is also clear that large effect mutations, such as the ones associated with antigenic cluster transitions (Koel et al., 2013) can play an important role in the evolution of human seasonal influenza viruses.”
- A Hemagglutinin Stem Vaccine Designed Rationally by AlphaFold2 Confers Broad Protection against Influenza B Infection (2022, unknown): “The serological methods were described previously [18].”
- The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin (2014, background): “This fact probably explains why HA is able to escape from antibodies targeting the periphery of the receptor-binding pocket (Koel et al., 2013), and why only rare antibodies that penetrate deep into this pocket are broadly neutralizing (Whittle et al.”