A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation

By Jiechao Ge, Minhuan Lan, Bingjiang Zhou, Weimin Liu, Liang Guo, Hui Wang, Qingyan Jia, Guangle Niu, Xing Huang, Hangyue Zhou and 5 more. Nature Communications, 2014

1,212 citations recorded by the source corpus.

Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (1O2) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce 1O2 via a multistate sensitization process, resulting in a quantum yield of ~1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of 1O2 quantum yield, water dispersibility, photo- and pH-stability, and biocompatibility. Photosensitisers are used in cancer therapy to promote the formation of reactive oxygen species on irradiation with light. Here, the authors present a graphene quantum dot photosensitiser with a singlet oxygen quantum yield of approximately 1.3, and investigate its in vitro and in vivoapplications

Subfields: Biomedical Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/d249718d5a0abb9a24bc58085dc052a5d0065118

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  1. Weifeng Chen
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