Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications.

By Chunyan Li, Guangcun Chen, Yejun Zhang, Feng Wu, Qiangbin Wang. Journal of the American Chemical Society, 2020

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Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital imaging capacity in the conventional wavelength range (400-950 nm) has been restricted by the extremely limited tissue penetration. To tackle this challenge, a novel imaging approach using the fluorescence in the second near-infrared window (NIR-II, 1000-1700 nm) has been developed in the last decade to achieve deep penetration and high-fidelity imaging, and thus significant biomedical applications have begun to emerge. In this Perspective, we first examine recent discoveries and challenges in the development of novel NIR-II fluorophores and compatible imaging apparatuses. Subsequently, the recent advances in bioimaging, biosensing, and therapy using such a cutting-edge imaging technique are highlighted. Finally, based on the achievement in the representative studies, we eluci-date the main concerns regarding this imaging technique and give some advice and prospects for the development of NIR-II imag-ing for future biomedical applications.

Subfields: Biomedical Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/d249271a607d504f1ec44c49be4795dca78d9189