A role for correlated spontaneous activity in the assembly of neural circuits
By L. Kirkby, Georgeann S Sack, Alana J Firl, M. Feller. Neuron, 2013
329 citations recorded by the source corpus.
Before the onset of sensory transduction, developing neural circuits spontaneously generate correlated activity in distinct spatial and temporal patterns. During this period of patterned activity, sensory maps develop and initial coarse connections are refined, which are critical steps in the establishment of adult neural circuits. Over the last decade there has been substantial evidence that altering the pattern of spontaneous activity disrupts refinement, but the mechanistic understanding of this process remains incomplete. In this review, we discuss recent experimental and theoretical progress towards the process of activity-dependent refinement, focusing on circuits in the visual, auditory and motor systems. While many outstanding questions remain, the combination of several novel approaches have brought us closer to a comprehensive understanding of how complex neural circuits are established by patterned spontaneous activity during development.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/d20bbc836147e6f7742f0089bb6bbb5b7adcc3ee
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In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
Citations in the corpus
- Homeostatic Activity-Dependent Tuning of Recurrent Networks for Robust Propagation of Activity (2015, background): “Activity-dependent adjustment of nascent synaptic connectivity is a widespread mechanism for tuning network properties in various parts of the developing brain (Kirkby et al., 2013).”