Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans

By T. Aitman, R. Dong, T. Vyse, P. Norsworthy, Michelle D. Johnson, Jennifer Smith, J. Mangion, Cheri Roberton-Lowe, Amy J. Marshall, E. Petretto and 12 more. Nature, 2006

712 citations recorded by the source corpus.

Subfields: Genetics, Nephrology

View Paper: https://www.semanticscholar.org/paper/d1faa397edd944fcf0961b37c2b52cc12d72b446

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Stephen W. Scherer
2. Chris Tyler-Smith
3. David Altshuler
4. Richard A. Gibbs
5. Steven A. McCarroll
6. Matthew E. Hurles
7. Greg Gibson

Citations in the corpus

• Mendelian Inheritance in Man and Its Online Version, OMIM (2007, neutral): “57 Gene duplication is a well-known basis of Mendelian disorders.”
• Personalized Copy-Number and Segmental Duplication Maps using Next-Generation Sequencing (2009, positive): “We conservatively validate 113 genes (Supplementary Table 6) as being variable in copy number among these three individuals (73-87 genes between two human genomes).”
• Copy number variation: new insights in genome diversity. (2006, background): “Most recently, Aitman et al. (2006) discovered copy number variation of the Fcgr3 gene in rats, which predisposed those animals carrying fewer gene copies to develop a condition similar to glomerulonephritis in humans.”