A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects

By H. Tjalsma, A. Boleij, Julian R. Marchesi, Bas E. Dutilh. Nature Reviews Microbiology, 2012

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Stool Microbiome and Metabolome Differences between Colorectal Cancer Patients and Healthy Adults (2013, background): “One hypothesis suggests that there are ‘‘driver bacteria’’ with pro-carcinogenic features that contribute to tumor development and ‘‘passenger bacteria’’ that may outcompete drivers to flourish in the tumor environment as the cancer progresses [47].”
Bacterial Biofilm and its Role in the Pathogenesis of Disease (2020, background): “Tomkovich et al. recently reported that human colon mucosal biofilms were carcinogenic in murine CRC-models, whether the biofilm associated microbiota were from CRC-patients or healthy individuals [104].”
Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor immune microenvironment (2013, background): “become the most highly enriched bacterium in colorectal tumors relative to adjacent tissue (Castellarin et al., 2012; Kostic et al., 2012; Tjalsma et al., 2012).”
The gut microbiota and host health: a new clinical frontier (2015, background): “89 Tjalsma et al 90 have also proposed the ‘ driver-passenger ’ model for CRC: a ﬁ rst hit by indigenous intestinal bacteria ( ‘ bacterial drivers ’ ), which drive the DNA damage that contributes to CRC initiation.”