Standardizing ADOS Scores for a Measure of Severity in Autism Spectrum Disorders
By K. Gotham, A. Pickles, Catherine Lord. Journal of Autism and Developmental Disorders, 2008
1,603 citations recorded by the source corpus.
The aim of this study is to standardize Autism Diagnostic Observation Schedule (ADOS) scores within a large sample to approximate an autism severity metric. Using a dataset of 1,415 individuals aged 2–16 years with autism spectrum disorders (ASD) or nonspectrum diagnoses, a subset of 1,807 assessments from 1,118 individuals with ASD were divided into narrow age and language cells. Within each cell, severity scores were based on percentiles of raw totals corresponding to each ADOS diagnostic classification. Calibrated severity scores had more uniform distributions across developmental groups and were less influenced by participant demographics than raw totals. This metric should be useful in comparing assessments across modules and time, and identifying trajectories of autism severity for clinical, genetic, and neurobiological research.
Subfields: Cognitive Neuroscience, Epidemiology, Genetics
View Paper: https://www.semanticscholar.org/paper/d1c3623b5f85482d995388aaf0a56d51b01d28bc
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cognitive Neuroscience
In Epidemiology
In Genetics
- Brian J. O'Roak
- G. Fischbach
- Evan E. Eichler
- Catherine Lord
- Jay Shendure
- Osnat Penn
- N. Katsanis
- Computational Pan-Genomics Consortium
Citations in the corpus
- The Simons Simplex Collection: a resource for identification of autism genetic risk factors. (2010, background): “Thus, the SSC represents a unique, well-described sample of able children Neuron 68 and adolescents with relatively severe ASD, as indicated by ADI-R and ADOS Calibrated Severity Scores (Gotham et al., 2009).”
- A Behavioral Comparison of Male and Female Adults with High Functioning Autism Spectrum Conditions (2011, neutral): “Recent attempts to revise the ADOS diagnostic algorithm to improve validity [73] and to create standardized ADOS scores [74] have excluded module 4 due to the possibly distinct behavioral phenotype of adults with ASC.”
- Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019, neutral): “We stratified donors using the standardized ADOS (StdADOS) score for disease severity (Gotham et al., 2009) into three groups: TD, MildASD (StdADOS = 4–5), or ASD (StdADOS = 6–10) (Figure 1B, Table S1).”
- Disruptive CHD8 mutations define a subtype of autism early in development (2014, methodology): “ASD severity, as measured with the calibrated severity score (Gotham et al., 2009), fell within the diagnostic realm (mean CSS = 6.8, SD = 1.3), underscoring the confidence of the diagnosis.”