Challenges of Antibacterial Discovery
By L. Silver. Clinical Microbiology Reviews, 2011
1,193 citations recorded by the source corpus.
Subfields: Microbiology, Molecular Medicine, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/d192faefbb523e4ba828fee53efa55f4e3d5eaf6
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Microbiology
In Molecular Medicine
In Organic Chemistry
Citations in the corpus
- Antibiotic resistance in Staphylococcus aureus. Current status and future prospects (2017, background): “Very few antibiotics that represent novel chemical classes have been introduced in the past 30 years (Silver 2011).”
- Predictive compound accumulation rules yield a broad-spectrum antibiotic (2017, neutral): “5: (1) ATCC 29213; (2) NRS3; (3) MG1655, (4) ELZ4017; (5) ELZ4045; (6) ELZ4346; (7) ELZ4081; (8) ELZ4072; (9) ELZ4239; (10) BAA-2469; (11) ATCC 19606; (12) KB304; (13) KB349; (14) WO22; (15) BD335; (16) IF101; (17) ATCC 27736; (18) 4-38; (19) 6-73; (20) ATCC 29893; (21) 1-60; (22) 3-46; (23) PAO1.”
- Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery (2014, background): “It has been discussed previously that interfering with the activity of multiple cellular targets is an important property of monotherapies needed to reduce the incidence of mutational resistance (Silver, 2011).”
- Low-N protein engineering with data-efficient deep learning (2020, background): “Consequently, the best candidates identified by early stage high-throughput (>10 4 variants) proxy experiments 9,11,14 will often fail in validation under higher-fidelity, later stage assays 13,15–17 .”
- Discovery of a structural class of antibiotics with explainable deep learning (2023, background): “The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis 1–9 .”
- Antimicrobial resistance: A global emerging threat to public health systems (2017, background): “More precisely, looking at the timeline of dates of discovery of distinct classes of antibacterials (as opposed to dates of introduction), there have been no successful discoveries of novel agents since 1987 (Silver, 2011).”