Genetically encoded indicators of neuronal activity

By Michael Z. Lin, Mark J. Schnitzer. Nature Neuroscience, 2016

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A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters (2018, positive): “We applied our strategy to the creation of genetically encoded fluorescent indicators of membrane potential 8 .”
Simulations approaching data: cortical slow waves in inferred models of the whole hemisphere of mouse (2021, positive): “In the last decade, macroscale wide-ﬁeld imaging, coupled with ﬂuorescent activity indicators (e.g., Genetically Encoded Calcium Indicators, GECIs [1–4]), has provided new insights on the study of brain activity patterns [5–13].”
Challenges and opportunities for large-scale electrophysiology with Neuropixels probes (2018, positive): “In the future, imaging of membrane-localized voltage sensors [51] or methods to elicit single spikes from individual neurons [52] may provide new ways to collect ground truth with higher throughput.”
Unsupervised Discovery of Demixed, Low-Dimensional Neural Dynamics across Multiple Timescales through Tensor Component Analysis (2017, background): “Recent experimental technologies enable us to record from more neurons, at higher temporal precision, and for 452 much longer time periods than ever before [4, 8, 11], thereby simultaneously increasing the size and complexity of 453 datasets along three distinct modes.”