Two chemosensory receptors together mediate carbon dioxide detection in Drosophila

By Walton D. Jones, P. Cayirlioglu, I. G. Kadow, Leslie B. Vosshall. Nature, 2007

659 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Ecology, Immunology

View Paper: https://www.semanticscholar.org/paper/d1718a5d6c06c5aa399bf68e3055f0a70b5987d5

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Citations in the corpus

Essential role of the mushroom body in context-dependent CO₂ avoidance in Drosophila. (2013, background): “We targeted a two-photon laser specifically to the V-glomerulus to photoactivate the PAGFP.”
Insect olfaction and the evolution of receptor tuning (2015, positive): “Examples include avoidance of carbon dioxide via GR21a and GR63a (co-expressed in the same OSN) (Jones et al., 2007; Kwon et al., 2007), aversion toward speciﬁc acids via IR64a (Ai et al., 2010), preference for yeast metabolites phenylacetaldehyde and phenylacetic acid via IR84a (Grosjean et al.,…”
Guard Cell Signal Transduction Network: Advances in Understanding Abscisic Acid, CO2, and Ca2+ Signaling (2010, background): “For example, in Drosophila, CO2 was reported to be sensed as an olfactory stimulus by a novel G protein-coupled receptor, although direct CO2 binding/interaction remains to be analyzed (75).”
Complementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems (2011, background): “Glomeruli receiving exclusively ipsilateral input, including the V glomerulus innervated by GR21a/GR63a neurons (Stocker et al., 1983; Scott et al., 2001; Couto et al., 2005; Jones et al., 2007; Kwon et al., 2007), are also grouped together in a posterior–ventral portion of the lobe (Fig.”
Molecular architecture of smell and taste in Drosophila. (2007, methodology): “∗Coexpression mentioned as possible but not validated in Couto et al. 2005. studies have shown that Gr21a and Gr63a together are sufficient to induce CO2 sensitivity when ectopically expressed in Or22aexpressing ORNs ( Jones et al. 2007, Kwon et al. 2007).”
Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. (2009, positive): “Extracellular recordings in single sensilla of 2- to 8-day-old flies were performed as described (Jones et al., 2007).”
Non-Canonical Odor Coding in the Mosquito (2020, background): “The response to acetone was abolished in the Gr3 mutant (Figure 8B), which suggests that the CO2 receptor can interact with non-CO2 ligands.”
The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity (2008, background): “ORs and GRs are primarily responsible for detecting odorants and tastants, respectively, but recent studies have suggested that some GRs recognize carbon dioxid”