Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients
By A. Eusebio, W. Thevathasan, L. Gaynor, A. Pogosyan, E. Bye, T. Foltynie, Ludvic U. Zrinzo, K. Ashkan, Tipu Z. Aziz, Peter Brown. Journal of Neurology Neurosurgery & Psychiatry, 2010
413 citations recorded by the source corpus.
Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity. Methods To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides. Results The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V. Conclusion The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.
Subfields: Cellular and Molecular Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/d137b90bbf40b0b4c659b26d1675d4f8e9ee3e75
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Citations in the corpus
- LFP and oscillations—what do they tell us? (2015, background): “However, studies using simultaneous MEG and STN-LFP recordings in DBS patients suggest that the pathophysiology is more complicated; functional connectivity in the beta band, manifest as cortico-STN coherence, is prominent and involves ipsilateral motor areas of the cortex [41,42].”