Directed enzyme evolution : screening and selection methods

By Frances H. Arnold, G. Georgiou. 2003

185 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d10a45ed5c6eeb75a656d8f03caf5bbd60af1d11

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Citations in the corpus

• Addressing the Numbers Problem in Directed Evolution (2008, background): “For example, in the quest to enhance the enantioselectivity of a lipase, we demonstrated some time ago that simultaneous randomization at a site composed of four amino acid (aa) positions next to the binding pocket is far more efficient than four consecutive rounds of epPCR, despite the fact that,…”
• Chemical and biochemical strategies for the randomization of protein encoding DNA sequences: library construction methods for directed evolution. (2004, unknown): “Advances in screening methodology have been reviewed elsewhere and will not be discussed here [see (6) for a recent review and papers in (7) for detailed protocols].”