Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients
By T. Rodrigues, K. S. D. de Sá, Adriene Y. Ishimoto, Amanda Becerra, Samuel Oliveira, Leticia Almeida, Augusto V. Gonçalves, Debora B. Perucello, W. Andrade, R. Castro and 34 more. Journal of Experimental Medicine, 2020
732 citations recorded by the source corpus.
This work shows that inflammasomes are activated in response to SARS-CoV-2 infection in vitro and in COVID-19 patients. Activation of inflammasomes in moderate and severe cases of COVID-19 contributes to the exacerbated inflammatory response, impacting disease progression and clinical outcome.
Subfields: Infectious Diseases, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/d1044274791465d940ac7e8f3f3c8bf76507dc0f
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In Molecular Biology
Citations in the corpus
- Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases (2022, background): “Other authors [35] demonstrated that in vitro monocyte infection by SARS-CoV-2 triggers caspase-1 activation, IL-1β and stimulates activation of the nucleotidebinding and oligomerization domain (NOD)-like receptor protein 3 (NLRP3, also known as “inflammasome”), thereby contributing to cell death.”
- Necroptosis, pyroptosis and apoptosis: an intricate game of cell death (2021, background): “For instance, recent evidence points to a correlation between COVID-19 severity and NLRP3 activation by SARS-CoV-2 infection.(99) Whether the activation of NLRP3 in these settings relates to its previously described sensing of viral RNA(100,101) or cellular perturbations remains to be investigated.”