Oxidative stress, dysfunctional glucose metabolism, and Alzheimer disease
By D. Allan Butterfield, Barry Halliwell. Nature Reviews Neuroscience, 2019
1,646 citations recorded by the source corpus.
Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully understand AD aetiology and pathogenesis, but oxidative damage is a key component. The brain mostly uses glucose for energy, but in AD and amnestic mild cognitive impairment glucose metabolism is dramatically decreased, probably owing, at least in part, to oxidative damage to enzymes involved in glycolysis, the tricarboxylic acid cycle and ATP biosynthesis. Consequently, ATP-requiring processes for cognitive function are impaired, and synaptic dysfunction and neuronal death result, with ensuing thinning of key brain areas. We summarize current research on the interplay and sequence of these processes and suggest potential pharmacological interventions to retard AD progression. Oxidative damage plays a key role in the development of Alzheimer disease. In this Review, Butterfield and Halliwell discuss how this damage relates to impaired brain glucose metabolism and proteostasis defects and how knowledge of it may suggest potential therapies.
Subfields: Molecular Medicine, Physiology
View Paper: https://www.semanticscholar.org/paper/d073f90c42aa184abd88fde2907bc8bfaab99a64
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- Changlong Li
- P. Huber
- Lu Zhang
- Adelina-Gabriela Niculescu
- Wei Gao
- Crina Ioana Radu
- B. Costachescu
- Xiao-Bo Zhou
Citations in the corpus
- NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential (2020, background): “, accumulation of protein carbonyls (PCs) in regions that are rich in Aβ-peptide-containing SPs, increased lipid peroxidation in AD and PCAD hippocampi and elevated DNA damage.(508) Recent studies have found that damaged cellular energy expenditure and DNA repair are related to the AD’s pathogenesis”
- An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases (2022, background): “sible for learning and memory, which are affected in AD brains [48].”