Discovering novel ligands for macromolecules using X-ray crystallographic screening

By V. Nienaber, P. Richardson, Vered Klighofer, J. Bouska, V. Giranda, J. Greer. Nature Biotechnology, 2000

297 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d03a6f1db2d497248903c5bde3a2e3c62e0d018d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Materials Chemistry

1. Roderick E. Hubbard

In Molecular Biology

1. Roderick E. Hubbard
2. D. Rees
3. Christopher W. Murray
4. Philip J. Hajduk
5. J. Greer
6. Jean-Louis Reymond
7. Gerhard Klebe

In Pharmacology

1. Roderick E. Hubbard
2. Philip J. Hajduk
3. J. Greer

Citations in the corpus

• A decade of fragment-based drug design: strategic advances and lessons learned (2007, background): “In 2000, Abbott published its first report on the use of X-ray crystallography for the detection and utilization of fragment lead”
• Fragment-based lead discovery (2004, background): “The same target, urokinase, has been the subject of a fragment screen using X-ray crystallograph”
• Structure-based drug discovery and protein targets in the CNS. (2011, methodology): “The first published account of fragment-based discovery came in 1996, when the Abbott group published the SAR by NMR approach (Shuker et al., 1996).”