Serum Ferritin: Past, Present and Future

By Wei Wang, M. A. Knovich, L. Coffman, Frank M. Torti, Suzy V. Torti. Biochimica et Biophysica Acta, 2010

838 citations recorded by the source corpus.

Background Serum ferritin was discovered in the 1930’s, and was developed as a clinical test in the 1970’s. Many diseases are associated with iron overload or iron deficiency. Serum ferritin is widely used in diagnosing and monitoring these diseases. Scope of Review In this chapter, we discuss the role of serum ferritin in physiological and pathological processes and its use as a clinical tool. Major Conclusions Although many aspects of the fundamental biology of serum ferritin remain surprisingly unclear, a growing number of roles have been attributed to extracellular ferritin, including newly described roles in iron delivery, angiogenesis, inflammation, immunity, signaling and cancer. General Significance Serum ferritin remains a clinically useful tool. Further studies on the biology of this protein may provide new biological insights.

Subfields: Cancer Research, Hematology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/d00b17aad2595993511c36583447c2475485ba03

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Citations in the corpus

• Ascorbic acid: Chemistry, biology and the treatment of cancer (2012, background): “In healthy individuals, iron is largely sequestered by iron binding proteins such as transferrin and ferritin [132,133].”