Fibrosis--a common pathway to organ injury and failure.

By Scott C. Weaver. New England Journal of Medicine, 2015

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Hepatic stellate cells as key target in liver fibrosis (2017, background): “ure in multiple epithelial organs such as liver, lung, and kidney, which is estimated to account for one-third of deaths worldwide [1].”
Kidney fibrosis: from mechanisms to therapeutic medicines (2023, background): “Fibrosis occurs when wound healing is deregulated, leading to excessive extracellular matrix (ECM) protein accumulation such as fibronectin and collagens.(9) When kidneys are injured, local fibroblasts and pericytes are activated, increasing their contractility, secreting inflammatory mediators, and”
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage (2019, neutral): “This process was performed iteratively using only the top cell types from the previous step and the variable genes among them until only one cell type remained (for details see Methods, Supplementary Information 1 and the SingleR Github repository at https://github.com/dviraran/SingleR ).”