The Ka/Ks ratio: diagnosing the form of sequence evolution.
By Laurence D. Hurst. Trends in Genetics, 2002
1,159 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d000a8c44b19b8658ae023ed950af6915f25a753
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Citations in the corpus
- SeqinR 1.0-2: A Contributed Package to the R Project for Statistical Computing Devoted to Biological Sequences Retrieval and Analysis (2007, methodology): “The Ka Ks ratio is used as tool to evaluate selective pressure (see [7] for a nice back to basics).”
- The interplay between structure and function in intrinsically unstructured proteins (2005, neutral): “2 [38].”
- γ-MYN: a new algorithm for estimating Ka and Ks with consideration of variable substitution rates (2009, methodology): “Most of the methods assume simplified nucleotide substitution paths and involve ad hoc data treatments that are not well-justified [5,6].”
- KaKs_Calculator 3.0: Calculating Selective Pressure on Coding and Non-coding Sequences (2021, background): “As synonymous substitutions do not provoke amino acid changes due to the degeneracy of the genetic code, they are expected to be invisible to selection and thus widely used as a reference that reflects the neutral rate of evolution [2].”
- Markers, old and new, for examining Phytophthora infestans diversity (2004, background): “The sequencing of a putative virulence gene from many isolates and analysis of the ratio of the mutations in the DNA sequence that result in a change (replacement or nonsynonomous) or no change (synonomous or silent) to the resultant amino acid yields the Ka/Ks ratio (Hurst, 2002).”
- Sequencing and comparison of yeast species to identify genes and regulatory elements (2003, methodology): “We tested this hypothesis by calculating the K a / K s ratio (the normalized ratio of amino-acid-altering substitutions to silent substitutions), a traditional test for positive selectio”