Strategies for discovering novel cancer biomarkers through utilization of emerging technologies

By V. Kulasingam, Eleftherios P. Diamandis. Nature Clinical Practice Oncology, 2008

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Liquid Biopsy: From Discovery to Clinical Application. (2021, methodology): “An assay with a 99% specificity being applied to 10 million individuals will lead to 100,000 false findings and considerable anxiety and cost (52).”
High-throughput proteomics: a methodological mini-review (2022, background): “1), proteomics holds a great promise for uncovering the molecular mechanisms that underlies diseases towards the discovery of novel biomarkers 8 and can be used as speci ﬁ c diagnostic assays, prognostic predictors, and therapeutic targets to enhance personalized medicine further 9,10 .”