Nanoparticle-based theranostic agents
By Jin Xie, Seulki Lee, Xiaoyuan Chen. Advanced Drug Delivery Reviews, 2010
1,321 citations recorded by the source corpus.
Theranostic nanomedicine is emerging as a promising therapeutic paradigm. It takes advantage of the high capacity of nanoplatforms to ferry cargo and loads onto them both imaging and therapeutic functions. The resulting nanosystems, capable of diagnosis, drug delivery and monitoring of therapeutic response, are expected to play a significant role in the dawning era of personalized medicine, and much research effort has been devoted toward that goal. A convenience in constructing such function-integrated agents is that many nanoplatforms are already, themselves, imaging agents. Their well developed surface chemistry makes it easy to load them with pharmaceutics and promote them to be theranostic nanosystems. Iron oxide nanoparticles, quantum dots, carbon nanotubes, gold nanoparticles and silica nanoparticles, have been previously well investigated in the imaging setting and are candidate nanoplatforms for building up nanoparticle-based theranostics. In the current article, we will outline the progress along this line, organized by the category of the core materials. We will focus on construction strategies and will discuss the challenges and opportunities associated with this emerging technology.
Subfields: Biomaterials, Biomedical Engineering
View Paper: https://www.semanticscholar.org/paper/cfbec9554e5d3d3154953db78a88b268cd06c0f0
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In Biomedical Engineering
Citations in the corpus
- Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems (2022, background): “By adjusting their sizes and shapes, surface chemistry and doping techniques, the designed MNPs can decompose rapidly under specific physiological conditions and are thereby easily absorbed by various metabolic pathways without affecting the healthy tissues [72].”
- Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases. (2016, background): “and silica NPs, carbon nanotubes and quantum dots [125].”
- Sol-gel based materials for biomedical applications (2016, background): “Moreover, several functionalities can be encapsulated into a single silica particle simultaneously [113,541,542].”