Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.

By Zhiyuan Yang, J. Yik, Ruichuan Chen, Nanhai He, M. Jang, K. Ozato, Qiang Zhou. Molecules and Cells, 2005

1,131 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cf74c1e1f6a684cb522333351b3d299156490575

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Citations in the corpus

BRD4 and Cancer: going beyond transcriptional regulation (2018, background): “Interaction with BRD4 prevents P-TEFb binding to the inhibitory ribonucleoprotein complex 7SK/ HEXIM that sequesters P-TEFb in its inactive form [43, 45].”
Targeting oncogenic Myc as a strategy for cancer treatment (2018, background): “BRD4 regulates transcription through recruitment of the positive transcription elongation factor b (PTEFb), which phosphorylates the carboxy-terminal domain of RNA polymerase II (pol II), to the site of hyperacetylated chromatin.(17)”
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia (2011, background): “g, Ribbon representation of the BRD4-BD1 (cyan) crystal structure complexed with I-BET151 (shown in magenta stick format) overlaid with H3(12-19)K14ac peptide (green) taken from its complex with BRD4-BD1(PDB ID 3jvk).”
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation (2010, background): “Indeed, physical associations (possibly indirect) between Mediator and the positive elongation factor P-TEFb, which is recruited to the TEC and promotes elongation, have also been observe”
Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription (2013, background): “cofactor Mediator and positive transcription elongation factor b (P-TEFb) (Jang et al., 2005; Yang et al., 2005).”
The mechanisms behind the therapeutic activity of BET bromodomain inhibition (2014, background): “Brd4 has been shown to regulate multiple steps of HIV transcription (Jang et al., 2005; Yang et al., 2005), and a series of recent studies have shown that BET inhibitors can trigger HIV transcription in latently infected cells, thus activating viral replication (Banerjee et al., 2012; Boehm et al.,…”
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers (2013, background): “BRD4 is known to interact with Mediator and P-TEFb and to be involved in the control of transcriptional elongation by RNAPol II (Conaway and Conaway, 2011; Dawson et al., 2011; Jang et al., 2005; Krueger et al., 2010; Rahman et al., 2011; Yang et al., 2005).”