The IPEC-J2 Cell Line

By H. Vergauwen. 2015

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IPEC-J2 cells are intestinal porcine enterocytes isolated from the jejunum of a neonatal unsuckled piglet. The IPEC-J2 cell line is unique as it is derived from the small intestine and is neither transformed nor tumorigenic in nature. IPEC-J2 cells mimic the human physiology more closely than any other cell line of non-human origin. Therefore, it is an ideal tool to study epithelial transport, interactions with enteric bacteria, effects of probiotic microorganisms and the effect of nutrients and other feedstuffs on a variety of widely used parameters (e.g. transepithelial electrical resistance (TEER), permeability, metabolic activity) reflecting epithelial functionality.

Subfields: Genetics, Neurology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/cf38212095b6143bea78bb791eb64ad9c54704e6