Loss of constitutive activity is correlated with increased thermostability of the human adenosine A2A receptor

By Nicolas Bertheleme, Shweta Singh, S. Dowell, J. Hubbard, B. Byrne. 2013

35 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

Citations in the corpus

• State-specific protein–ligand complex structure prediction with a multiscale deep generative model (2022, neutral): “…no apo experimental structure has been determined for this target, structure alignment with the G-protein-bound active conformation 52 (PDB:6GDG) suggests that the sampled ligand-free structures are plausible states that may be attributed to constitutive activity in the absence of ligands 53 .”