Prevalence of Dry Eye Disease among US Men: Estimates from the Physicians’ Health Studies

By D. Schaumberg, R. Dana, J. Buring, D. Sullivan. A M A Archives of Ophthalmology, 2009

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Objective To estimate the prevalence and risk factors for DED among US men. Methods Cross-sectional prevalence survey among male participants aged 50y and older in the Physicians’ Health Studies I (N=18,596) and II (N=6,848). We defined DED as the presence of clinically diagnosed dry eye or severe symptoms (both dryness and irritation constantly or often). We calculated the age-standardized prevalence of DED adjusted to the age distribution of US men in 2004, and projected estimates forward to 2030. We compared DED prevalence to a similar cohort of women, and examined associations with possible risk factors. Results The prevalence of DED increased with age, from 3.90% among men 50–54y old to 7.67% among men 80y and older (P for trend <0.0001). High blood pressure (OR=1.28; CI=1.12–1.45) and benign prostatic hyperplasia (OR=1.25; CI=1.09–1.44) were associated with a higher risk of DED. Use of antidepressants, antihypertensives, and medications to treat benign prostatic hyperplasia were also associated with increased risk of DED. The age-standardized prevalence of DED was 4.34%, or 1.68 million men aged 50y or older, and is expected to affect over 2.79 million US men by 2030. Conclusions DED is prevalent and increases with age, hypertension, benign prostatic hyperplasia and antidepressants.

Subfields: Dermatology, Public Health, Environmental and Occupational Health, Urology

View Paper: https://www.semanticscholar.org/paper/ced5a79af4ea51f707dc47636028721e18b75385

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