Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

By Katharina Gapp, A. Jawaid, P. Sarkies, J. Bohacek, P. Pelczar, J. Prados, Laurent Farinelli, E. Miska, I. Mansuy. Nature Neuroscience, 2014

1,158 citations recorded by the source corpus.

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ced02738287f927397457b14bfd9f11e70f8e8f5

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Citations in the corpus

• Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress (2015, background): “Studies in which manipulation of total RNA content in postfertilization zygotes reproduced aspects of a paternally transmitted phenotype highlight the critical importance of RNA as a germ cell epigenetic mark and support the potential role of small RNAs, including microRNAs (miRs), in trait transmis”
• A review of the potential effects of suspended sediment on fishes: potential dredging-related physiological, behavioral, and transgenerational implications (2015, background): “Many studies, e.g., Franklin and Mansuy (2010), Gillette et al. (2014), Christopher (2014), Gapp et al. (2014), and Missios et al. (2014), in mammals have shown that several stress-induced outcomes, such as DNA methylation and telomere length, can affect an individual’s health, thereby impacting…”