Impacts of the ubiquitous factor Zelda on Bicoid-dependent DNA binding and transcription in Drosophila
By Zhe Xu, Hongtao Chen, Jia Ling, Danyang Yu, P. Struffi, S. Small. 2014
104 citations recorded by the source corpus.
The Drosophila transcription factor Bicoid (Bcd) binds thousands of genomic sites during early embryogenesis, but it is unclear how many of these binding events are functionally important. Here, Small and colleagues test the role of the maternal factor Zelda (Zld) in Bcd-mediated binding and transcription. Embryos lacking Zld show enhanced Bcd binding to a subset of genomic locations, causing early activation of target genes normally silent until later stages. This study demonstrates a critical role for Zld in controlling Bcd binding and target gene activation in the early embryo.
Subfields: Molecular Biology
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In Molecular Biology
- Bin Yu
- Karl Kumbier
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Citations in the corpus
- Iterative random forests to discover predictive and stable high-order interactions (2017, positive): “This generalizes the dependence of Bicoid-induced transcription on Zld binding to several of the AP factors (36) and is broadly consistent with the idea that Zld is potentiating, rather than an activating factor (35).”
- Zelda is differentially required for chromatin accessibility, transcription factor binding, and gene expression in the early Drosophila embryo (2015, methodology): “Data for Bcd binding in wild-type and zldM- embryos were from GSE55256 (Xu et al. 2014).”