Guidelines for performing Mendelian randomization investigations
By Stephen Burgess, G. Davey Smith, N. Davies, Frank Dudbridge, D. Gill, M. M. Glymour, F. Hartwig, Zoltán Kutalik, Michael Holmes, Cosetta Minelli and 4 more. Wellcome Open Research, 2019
2,022 citations recorded by the source corpus.
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.
Subfields: Genetics
View Paper: https://www.semanticscholar.org/paper/ce814345c7c9f565b80cb4a82535f2045e1a1181
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In Genetics
- E. Sanderson
- Michael Holmes
- T. Palmer
- Mika Ala-Korpela
- B. Ference
- T. Richardson
- George Davey Smith
- J. Bowden
Citations in the corpus
- Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis (2020, methodology): “The repertoire of robust univariable MR approaches [51] that seek to act as sensitivity analyses for potential unbalanced horizontal pleiotropy each make a different series of assumptions [53].”
- Neither VitD nor VitD binding protein or VitD receptor has causal effect on cancers: a Mendelian randomization study (2025, unknown): “For 25OHD and VDBP, causality was primarily estimated using the inverse variance weighted (IVW) method [18].”