Tumor-associated macrophages: an accomplice in solid tumor progression

By Yibing Chen, Yucen Song, W. Du, Longlong Gong, Haocai Chang, Zhengzhi Zou. Journal of Biomedical Sciences, 2019

930 citations recorded by the source corpus.

In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor patients. In this review, we describe the origins of TAMs and their polarization state dictated by the TME. We also specifically focus on the role of TAMs in promoting tumor growth, enhancing cancer cells resistance to chemotherapy and radiotherapy, promoting tumor angiogenesis, inducing tumor migration and invasion and metastasis, activating immunosuppression. In addition, we discuss TAMs can be used as therapeutic targets of solid tumor in clinics. The therapeutic strategies include clearing macrophages and inhibiting the activation of TAMs, promoting macrophage phagocytic activity, limiting monocyte recruitment and other targeted TAMs therapies.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/ce494fb6a90b18166f259a1af0bbdb64e186315e

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Citations in the corpus

• Tumor microenvironment complexity and therapeutic implications at a glance (2020, background): “For one, TAM strengthens angiogenesis by production of VEGF-A, TNFα, urokinase plasminogen activator (uPA), FGF, adrenomedullin (ADM), and semaphorin 4D (Sema4D) thymidine phosphorylase (TP), lymphangigensis (secretion of VEGF-A, VEGF-C, VEGF-D, CXCL8, MMP2, MMP9) fueling cancer invasion and metasta”