Genome-wide meta-analyses identify multiple loci associated with smoking behavior

By H. Furberg, Yunjung Kim, J. Dackor, Eric Boerwinkle, N. Franceschini, D. Ardissino, L. Bernardinelli, P. Mannucci, F. Mauri, P. Merlini and 106 more. Nature Genetics, 2010

1,140 citations recorded by the source corpus.

Consistent but indirect evidence has implicated genetic factors in smoking behavior. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (n > 140,000). We identified three loci associated with number of cigarettes smoked per day. The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], β = 1.03, standard error (s.e.) = 0.053, P = 2.8 × 10−73). Two 10q25 SNPs (rs1329650[G], β = 0.367, s.e. = 0.059, P = 5.7 × 10−10; and rs1028936[A], β = 0.446, s.e. = 0.074, P = 1.3 × 10−9) and one 9q13 SNP in EGLN2 (rs3733829[G], β = 0.333, s.e. = 0.058, P = 1.0 × 10−8) also exceeded genome-wide significance for cigarettes per day. For smoking initiation, eight SNPs exceeded genome-wide significance, with the strongest association at a nonsynonymous SNP in BDNF on chromosome 11 (rs6265[C], odds ratio (OR) = 1.06, 95% confidence interval (Cl) 1.04–1.08, P = 1.8 × 10−8). One SNP located near DBH on chromosome 9 (rs3025343[G], OR = 1.12, 95% Cl 1.08–1.18, P = 3.6 × 10−8) was significantly associated with smoking cessation.

Subfields: Genetics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/ce405501b333ddbdd3fbc283c45a102d35133fbe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Jingsi Ming
2. Xianghong Hu
3. Can Yang
4. Jin Liu
5. Jia Zhao
6. Gang Chen
7. Daniel Marbach

In Molecular Biology

1. Sven Bergmann
2. Can Yang
3. Zoltán Kutalik
4. Daniel Marbach
5. Rico Rueedi
6. David Lamparter

Citations in the corpus

• Bayesian weighted Mendelian randomization for causal inference based on summary statistics (2018, background): “…SW subjective well being 298,420 (Okbay et al., 2016) Social Trait TAG age onset 47,961 (Furberg et al., 2010) Social Trait TAG cigs per day 68,028 (Furberg et al., 2010) Social Trait TAG ever smoked 74,035 (Furberg et al., 2010) Social Trait TAG former smoker 41,969 (Furberg et al.,…”