Epidemiology and Surveillance for Hepatocellular Carcinoma: New Trends

By Amit G. Singal, P. Lampertico, P. Nahon. Journal of Hepatology, 2020

976 citations recorded by the source corpus.

SUMMARY Hepatocellular carcinoma (HCC) burden is highest in East Asia and Africa, although its incidence and mortality are rapidly rising in the United States and Europe. With implementation of hepatitis B vaccination and hepatitis C treatment programs worldwide, there is a shift in HCC epidemiology from a viral-hepatitis predominant disease to an increasing proportion of cases from non-alcoholic steatohepatitis (NASH). Surveillance using ultrasound with or without alpha fetoprotein every 6 months has been associated with improved early detection and improved overall survival; however, limitations in implementation lead to a high proportion of HCC being detected at late stages in clinical practice. Herein, we review the current state of HCC surveillance and highlight areas for future research including improved risk stratification of at-risk patients, surveillance tools with higher sensitivity and specificity for early HCC, and interventions to increase surveillance utilization.

Subfields: Epidemiology, Hepatology

View Paper: https://www.semanticscholar.org/paper/cdc623c66e0ab7f435152278952bc5dfeed3d73e

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In Epidemiology

  1. J. Llovet
  2. Amit G. Singal
  3. F. Kanwal

In Hepatology

  1. Amit G. Singal
  2. F. Kanwal
  3. J. Llovet
  4. Jordi Bruix1 , 2
  5. Riccardo Lencioni

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