Copy number variation and selection during reprogramming to pluripotency

By Samer M. I. Hussein, Nizar N. Batada, S. Vuoristo, R. Ching, R. Autio, Elisa Närvä, Siemon H. S. Ng, Michel Sourour, R. Hämäläinen, Cia Olsson and 10 more. Nature, 2011

977 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cd9504c7093927a509837a02d023536653255013

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. A. Cheng
2. Xiangdong Meng
3. R. Jaenisch
4. Yi Zhang
5. A. Bird
6. Robert Poulin

In Molecular Biology

1. A. Cheng
2. F. Soldner
3. Susan Lindquist
4. Xiangdong Meng
5. F. Urnov
6. D. Hockemeyer
7. E. Rebar
8. R. Jaenisch

Citations in the corpus

• Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations (2011, positive): “We therefore performed high-resolution genome-wide CNV analysis using an Affymetrix SNP 6.0 array, as described previously (Hussein et al., 2011; Närvä et al., 2010), on three pairs of isogenic parental and genetically modified cell lines.”
• Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts (2011, background): “While epigenetic and transcriptomic differences have been mentioned above [9,10] other significant genetic changes in IPSCs when compared to hESCs and differentiated cells were also recently described [11,12], including higher mutation rates and copy number variation.”